| 1. | The small molecule causing the conformational change is an allosteric effector .
引起结构变化的小分子叫做变构效应场。 |
| 2. | The results of md simulations are very useful to understand the relation between the macromolecular conformational changes and its biological function
Md模拟对于研究蛋白质等生物大分子的结构与功能的关系具有重要的意义。 |
| 3. | During hydrolization of atp , conformational changes occur within the motor protein ( a mechanochemical process ) , and mechanical work is done
分子马达通过催化三磷酸腺苷分子( atp )水解，将化学能转化为机械能产生自身的定向运动。 |
| 4. | In this paper , we consider more of the conformational changes in the process of atp ' s hydrolysis and the complex structure of microtubule
基于这种情况，本论文进一步考虑了驱动蛋白在实际运动中，尤其是在atp水解为adp过程中的构象变化以及微管结构的复杂性。 |
| 5. | By exploiting recent technical advances , we are able to observe , detect , even manipulate individual molecules and study their conformational changes and dynamic behaviors
近来，科学技术的探索发展使我们可以观察、检测甚至操纵单个分子并且研究它们的构象变化和动力学行为。 |
| 6. | We can take molecular motor as a brownian particle in the case of ignoring the conformational changes . the interaction between motor and microtubule can be described by a special potential function and the effect of the environment can be simplified as a noise
在不考虑分子马达构象变化的情况下，通常把分子马达抽象为布朗粒子，用一个特定的势函数来表示轨道与马达的相互作用，环境的影响可以简化为特定形式的噪声激励。 |
| 7. | Abstract : the effects of terbium ion on the conformation of calmodulin and on the interaction between calmodulin and melittin have been studied by the endogenous fluorescent spectrometry of calmodulin and melittin , and the sensitized fluorescent spectrometry of terbium ion , respectively . the results show that terbium ions have a tight binding site in the i and ii metal - binding sites of calmodulin . the conformation of calmodulin induced by terbium ion can bind melittin and transfer the tryptophane residue of melittin to a relatively hydrophobic environment , while the binding of melittin to calmodulin produces effect on the binding orders of terbium ion in camodulin . results from ft - ir spectrometry have revealed that upon binding of lanthanum ion , apo - calmodulin undergoes a conformational change with the increase of - helix content and the decrease of - sheet content . melittin ' s binding to calmodulin has no effect on its conformation induced by the binding of lanthanum ion to calmodulin
文摘:分别用钙调蛋白和蜂毒素的内源荧光光谱以及铽离子的敏化荧光光谱考察了铽离子对钙调蛋白构象变化以及对钙调蛋白与蜂毒素相互作用的影响.结果表明，铽离子首先结合在钙调蛋白的第和第位点，铽离子不影响钙调蛋白与蜂毒素的相互作用，蜂毒素与钙调蛋白作用后不影响铽离子在钙调蛋白上的键合顺序.傅里叶变换红外光谱结果表明三价的镧离子与钙调蛋白作用使钙调蛋白的螺旋结构增加，折叠结构减少，与钙离子对它的二级结构影响相类似.稀土离子在钙调蛋白-蜂毒素复合体系中主要与钙调蛋白作用 |
| 8. | The results indicate that because of the improvement in two aspects mentioned above , the successful probability of the docking prediction is increased from unbound structures . for the case of enzyme trypsin - inhibitor appi , although the large conformational change occurs to the arg 15 side chain of appi upon complex formation , the native - like structure was still found and ranked first
其中，在胰蛋白酶appi复合物结构预测中，尽管抑制剂appi的15号残基arg侧链在复合物形成过程中发生了较大的构象变化，但其近天然结构仍然被找到了，并在打分中排在了第一位。 |
| 9. | Because the large conformational changes occurring upon complex formation are frequently confined to the protein surface , especially for the side chains of flexible amino acids arg , lys , asp , glu and met , the locations of the mass centers and the values of radii of these residues are modified for modeling protein surface . this tolerates overlap in some degree between the amino acid side chains on the surfaces of the receptor and the ligand
由于蛋白质表面氨基酸残基arg 、 lys 、 asp 、 glu和met具有较大的柔性，因此，北京工业大学工学博士学位论文一我们对蛋白质分子表面的这五种氨基酸模型作了修正，调整了残基球心的位置和半径的数值，使分子表面的氨基酸残基在对接时具有一定程度的可交叠性。 |
